Document 0459
 DOCN  M9480459
 TI    Serum collagen type IV for the assessment of fibrosis and resistance to
       interferon therapy in chronic hepatitis C.
 DT    9410
 AU    Yabu K; Kiyosawa K; Mori H; Matsumoto A; Yoshizawa K; Tanaka E; Furuta
       S; Second Dept. of Internal Medicine, Shinshu University School of;
       Medicine, Matsumoto, Japan.
 SO    Scand J Gastroenterol. 1994 May;29(5):474-9. Unique Identifier :
       AIDSLINE MED/94310405
 AB    Sixty-nine patients with chronic hepatitis C (CH-C) were treated with
       interferon therapy, and serum collagen type IV (s-collagen IV) levels
       were measured by enzyme immunoassay to analyze the responsiveness to
       interferon therapy. Classified by the improved pattern of serum alanine
       aminotransferase levels after interferon administration, 23 patients
       were judged as sustained responders, 23 as transient responders, and 23
       as non-responders. Fibrotic grades of the liver sample correlated
       statistically with the levels of s-collagen IV (P < 0.01). Pre-therapy
       s-collagen IV levels of sustained responders were significantly lower
       than those of the other responders, and only sustained responders showed
       a significant decrease of s-collagen IV levels after interferon therapy,
       in accordance with histologic improvement. Multivariate analysis showed
       that s-collagen IV and hepatitis C virus genotype were the most
       important factors affecting the response to interferon therapy of all
       variates. Thus, s-collagen IV is one of the most useful aids for the
       evaluation of liver fibrotic grade in CH-C and a potent predicting
       indicator for the responsiveness to interferon therapy.
 DE    Adult  Aged  Base Sequence  Chronic Disease  Collagen/*BLOOD  Drug
       Resistance  Female  Hepatitis C/COMPLICATIONS/*PATHOLOGY/*THERAPY
       Hepatitis C Viruses/GENETICS  Human  Interferons/*THERAPEUTIC USE
       Liver/PATHOLOGY  Liver Cirrhosis/*DIAGNOSIS/ETIOLOGY  Male  Middle Age
       Molecular Sequence Data  Multivariate Analysis  Polymerase Chain
       Reaction  RNA, Viral/ANALYSIS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).